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ClpP inhibitor M21

CAS No. 1151944-58-9

ClpP inhibitor M21( —— )

Catalog No. M10535 CAS No. 1151944-58-9

ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ClpP inhibitor M21
  • Note
    Research use only, not for human use.
  • Brief Description
    ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM.
  • Description
    ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM, inhibits ClpP cleavage of SUc-LY-AMC substrate in a peptidase assay; alters α-toxin expression in a ClpP-dependent manner and attenuate S. aureus virulence via ClpP inhibition; blocks the pathogenicity of infection in animal models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1151944-58-9
  • Formula Weight
    385.452
  • Molecular Formula
    C19H15NO4S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C(C=C1)COC2=CC=C(C=C2)C=C3C(=O)N(C(=S)S3)CC(=O)O
  • Chemical Name
    (Z)-2-(5-(4-(benzyloxy)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gao P, et al. Proc Natl Acad Sci U S A. 2018 Jul 16. pii: 201720520.
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